Researchers at Cornell University in Ithaca, N.Y., have developed a surgical procedure on a mouse spinal cord to better understand and treat spinal cord pathology, according to an article in Nature Methods.
The researchers developed a chronically implanted spinal chamber suitable for time-lapse in vivo multiphoton microscopy without the need for repeat surgical procedures. The procedure derived from routine, repeated images of mice over five postoperative weeks during 10 separate imaging sessions.
During development, neither motor-function deficits nor neuropathology in the spinal cord resulted from the chamber implantation. Massive microglia infiltration within 1 d along with a heterogeneous dieback of axon stumps were observed after a laser-induce spinal cord lesion.
According to the article, the researchers’ method offers a platform for understanding cellular dynamics in response to injury and therapeutic interventions.
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During development, neither motor-function deficits nor neuropathology in the spinal cord resulted from the chamber implantation. Massive microglia infiltration within 1 d along with a heterogeneous dieback of axon stumps were observed after a laser-induce spinal cord lesion.
According to the article, the researchers’ method offers a platform for understanding cellular dynamics in response to injury and therapeutic interventions.
Related Articles on Spine Procedures:
Amedica Launches New Spinal Fusion Device
Greater Bone Cement Injections Can Help Deformity Corrections After Vertebroplasty
Study: Modified Approach to Interlaminar Lumbar Epidural Ateroid Injections Safer, More Effective